In peer-reviewed molecular research published in Advanced Science, an international research team discovered a major reason why hair roots shrink: a localized breakdown in how scalp cells consume and process an essential amino acid called L-arginine.
Historically, Dimethylglycine (DMG)—specifically its sodium salt, Sodium Dimethylglycinate (DMG-Na)—was primarily known as an athletic and metabolic supplement. However, recent dermatological research has introduced it as a topical agent for treating androgenetic alopecia (hereditary male pattern baldness).
Topical Thyromimetic-Mediated Activation of Thyroid Hormone Receptors and Follicle Stem Cells Achieves a 24.3 Hairs/cm² Target Area Hair Count Increase in Phase 2a Clinical Trial.
A major regulatory breakthrough was announced on April 28, 2026, as a once-daily pill called upadacitinib (brand name Rinvoq) was officially submitted to the FDA for the treatment of severe Alopecia Areata. This treatment has made history as the first of its kind to prove it can regrow 100% of lost scalp hair in a significant number of patients during the final stage of medical testing.
New data released today, April 21, 2026, reveals that a groundbreaking liquid treatment called GT20029 is successfully regrowing hair by acting like a heat-seeking missile for the root cause of baldness. Instead of just blocking harmful hormones, it literally shreds the “docking ports” they use to attack your hair.
New data released today, April 20, 2026, shows that a first-of-its-kind treatment called rezpegaldesleukin is successfully regrowing hair in people with severe Alopecia Areata by “resetting” their immune system rather than just turning it off.
Senolytic topicals are designed to target and remove senescent cells—cells that have stopped dividing and contribute to aging and tissue damage. These topicals may have potential in reducing hair loss when applied to the scalp by rejuvenating hair follicles and improving the scalp environment. Take a look at this…
I decided to look into which studies have generated the most hairs and what exactly they did. It turns out Mnixodil and microneedling are currently the best way known to generate new hairs. In the study they generated 91 new hairs over 12 weeks on average. Here’s how they did it and how you can easily copy them….
I’ve mentioned previously how inflammation causes hair loss and how important it is to prevent/reduce inflammation as you age. So I thought this would be an incredibly useful article — use this page as a guide to help you prevent/reduce inflammation as cost effectively as possible.
We know treatments like Finasteride that reduce DHT are effective at reducing hair loss, but they also have side effects. However, topical DHT blockers have far fewer side effects and are still powerful hair loss treatments. So, what are they and how can you use them?
A very intriguing thing has been discovered about resveratrol. It decreases something called PGD2.
In a study of scalps, bald and balding scalps were found to have very high levels of PGD2.
Further research has shown that PGD2 is linked to inflammatory cytokines, which make the hair transition to the shedding phase. Reducing PGD2 can reduce hair loss by keeping the hair in the growth phase!
Since it’s also incredibly good for your health it’s a win-win. Check this out and see which supplement I personally use…
Anthralin is an anti inflammatory cream that works by suppressing cytokines.
The chemical adenosine has been shown to lengthen the growth phase of the hair follicles. It may do this by improving blood circulation in the scalp, enabling a greater supply of nutrients to flow to the hair.
Luteolin is a flavonoid found in many plants, which can reduce hair loss by reducing scalp PGD2. It’s another interesting example of an anti-allergy treatment, which translates well as a hair loss treatment.
Biotin is included in loads of hair loss treatments — shampoos, topicals, supplements. But does it actually increase hair growth? And if so, how exactly?
Melatonin is a powerful antioxidant, which has been shown in several studies to have significant positive effects on hair growth in patients suffering from hair loss. Let’s see how it works and how you can use it…
Insulin-like Growth Factor 1 (IGF-1) is a growth factor that’s been shown to increase hair growth when the growth factor is increased in the scalp. In this article, I explain how you can increase IGF-1 in your scalp in order to increase hair growth.
Difenciprone, or diphenylcyclopropenone has been used topically to stimulate hair growth in patients with Alopecia Areata with some success. So, is it worth trying for people with other types of hair loss, such as male pattern baldness?
Saw Palmetto is one of the most popular natural treatments for hair loss and with just a quick search online you can see thousands of articles about it. But does it really work? Is there any science backing up the cult following surrounding this plant?
Beta Sitosterol is a powerful natural plant extract taken from saw palmetto. It’s an anti androgen: it prevents testosterone from converting to DHT. DHT is the primary cause of male pattern hair loss.
Redensyl seems to be the ultimate hair loss treatment — particularly for male pattern baldness. It’s anti inflammatory, anti androgen and studies claim it improves blood circulation in the scalp as effectively as Minoxidil.
Diclofenac is the active ingredient in Voltarol anti-inflammatory gel, so it’s not surprising to me that when applied to the scalp of balding men, it triggers new hair growth by reducing inflammation (a key cause of male pattern baldness).
Topical Latanoprost was discovered to significantly increase eye lash growth, making it a world-wide sensation. But it also seems it can be used to increase scalp hair growth. Here’s how to do it…
The Numan subscription is a Minoxidil spray, a vitamins supplement and a prescription drug called Finasteride. But does it actually work or is it all just clever marketing? Let’s find out…
Put simply, PTD-DBM is a peptide that inhibits a protein called CXXC5. CXXC5 prevents hair growth. Using PTD-DBM we can prevent CXXC5 from interfering with hair growth. Here’s how…
Cetirizine is a cheap anti-allergy medication. It’s thought to reduce PGD2 when applied to the scalp. In one experiment, 1% cetirizine was applied to the scalps of subjects and ‘significant hair growth’ was reported.
Way 316-606 reduces hair loss and promotes hair growth by blocking SFRP1 from damaging hair follicles in the scalp. SFRP1 is a protein that interferes with hair growth. By blocking the protein, hair grows uninhibited.
Androgenic alopecia (AGA), also called male-pattern baldness, is the most common form of hair loss and has been associated with other dysfunctions such as coronary heart disease and an enlarged prostate. It seems that PGD2 prevents the hair follicles from maturing There have been numerous studies concerning androgenic alopecia but more data is needed to […]
CB 03 01 is a topical hair loss treatment that works by binding with androgen receptors in the hair follicles, helping to reduce the amount of DHT that’s able to bind with the receptors.
Full ingredients list Aqua Alcohol denat. PPG-26-buteth-26 PEG-40 hydrogenated castor oil Menthol Butylene glycol Keratin Phenethyl alcohol Ethyltrimonium chloride methacrylate/Hydrolyzed wheat protein copolymer Caprylyl glycol Menthyl lactate PEG-5 cocomonium methosulfate Apigenin Biotinoyl tripeptide-1 Oleanolic acid Sphinganine Sodium glutamate Hydrolyzed collagen Hydrolyzed soy protein Lauryldimonium hydroxypropyl hydrolyzed soy protein Sodium cocoyl glutamate Glycine Hydroxypropyl guar hydroxypropyltrimonium […]
